[关键词]
[摘要]
异基因造血干细胞移植(allo-HSCT)是治疗多种血液系统恶性肿瘤的主要方法，但术后的慢性移植物抗宿主病(cGVHD)是一种常见的并发症，其中眼部移植物抗宿主病(oGVHD)是最常见的一种，主要累及泪腺、睑板腺、角膜和结膜，典型症状为以纤维化为特征的干眼综合征。oGVHD相关干眼导致患者生活质量显著下降，已引起广泛关注。oGVHD的治疗除了应用全身免疫抑制剂和眼润滑剂外，通常联合局部使用糖皮质激素和环孢素。对于中重度oGVHD较新的治疗措施还包括使用自体血清滴眼液和角巩膜接触镜。本文主要就oGVHD及其相关干眼的治疗现状进行综述，以期为临床诊疗提供思路。
[Key word]
[Abstract]
Allogeneic hematopoietic stem cell transplantation(allo-HSCT)is the main treatment for a variety of hematological malignancies, but chronic graft-versus-host disease(cGVHD)is subsequently a common complication. Among them, ocular graft-versus-host disease(oGVHD)is the most common one, which mainly involves lacrimal glands, eyelid glands, cornea, and conjunctiva. The typical syndrome is dry eye syndrome characterized by fibrosis. The oGVHD-related dry eye has led to a significant reduction in the quality of life of patients, which has attracted widespread attention. In addition to systemic immunosuppressant and ocular lubricants, topical corticosteroids and cyclosporine are usually used in combination for the treatment of oGVHD. Newer treatments for moderate to severe oGVHD also include the use of autologous serum eye drops and scleral contact lenses. This article mainly reviews the current treatment status of oGVHD and dry eye, with a view to provide ideas for clinical diagnosis and treatment.
[中图分类号]
[基金项目]
广东省临床用药研究基金项目(No.2019XQ10)
