目的：探讨生物羊膜覆盖联合角膜绷带镜治疗眼表化学性烧伤患者的临床效果及生物羊膜的稳定性。

方法：回顾性研究。选取2018-12/2021-08在我院治疗的眼表化学性烧伤患者49例49眼的临床资料，按照手术方式分为单纯羊膜覆盖组25眼和羊膜覆盖术后配戴角膜绷带镜组24眼。比较两组患者的羊膜脱落时间、术后疼痛评分、眼表修复率及修复时间、术后视力和并发症情况。

结果：单纯羊膜覆盖组和羊膜覆盖术后配戴角膜绷带镜组患者术后1d眼部疼痛评分为2.208±0.758和2.063±0.800分(P>0.05)，术后3d为1.844±0.762和1.150±0.582分，术后7d为1.684±0.820和0.750±0.514分(均P<0.05)。羊膜覆盖术后配戴角膜绷带镜组羊膜脱落时间为10.75±2.63d，比单纯羊膜覆盖组(7.60±2.22d)更长(P<0.05)，且角膜修复效果较单纯羊膜覆盖组更好。术后6mo，两组患者视力分别为0.30(0.10，0.55)和0.30(0.20，0.58)(P>0.05)，两组患者并发症发生情况无差异(P>0.05)。

结论：生物羊膜覆盖可以有效地治疗眼表化学性烧伤，联合角膜绷带镜治疗可以延缓其脱落时间，提高角膜修复率，降低患者术后不适程度。

METHODS: Retrospective study. The clinical data of 49 cases(49 eyes)of patients with chemical burns of ocular surface treated in our hospital between December 2018 and August 2021 were collected. They were divided into the biological amnion membrane coverage group and the biological amnion membrane coverage combined with corneal bandage lens group according to the surgical method. The loss time of biological amniotic membrane, postoperative pain score, repair rate and time of ocular surface, visual acuity and complications were compared between the two groups.

RESULTS: The ocular pain scores of the two groups were 2.208±0.758(the biological amnion membrane coverage group)and 2.063±0.800(the biological amnion membrane coverage combined with corneal bandage lens group)at 1d after surgery, respectively(P>0.05). But at the 3d and 7d after surgery, pain scores were 1.844±0.762 and 1.150±0.582, 1.684±0.820 and 0.750±0.514, respectively(all P<0.05). The loss time of biological amniotic membrane in the biological amnion membrane coverage combined with corneal bandage lens group was 10.75±2.63d, which was longer than that in the biological amnion membrane coverage group(7.60±2.22d; P<0.05). Moreover, it has better ocular surface repair effect than the biological amnion membrane coverage group. At 6mo after operation, visual acuity in the two groups was 0.30(0.10, 0.55)and 0.30(0.20, 0.58), respectively(P>0.05). Additionally, there was no differences in the complications of both groups(P>0.05).

CONCLUSION:Biological amnion membrane coverage has effective treatment effects on patients with chemical burns of ocular surface, and it can delay the loss time of biological amniotic membrane, increase repair rate of ocular surface and alleviate postoperative discomfort if combined with corneal bandage lens.