目的：对比观察原发性视网膜色素变性(RP)的低视力患者在配戴琥珀色滤光镜前后的视觉功能变化。

方法：自身前后对照研究。收集2021-08/2022-03就诊于西安市第一医院眼科门诊诊断为原发性RP的低视力患者30例60眼。记录配戴琥珀色滤光镜前后裸眼远视力(UCDVA)、最佳矫正远视力(BCDVA)、裸眼近视力(UCNVA)、最佳矫正近视力(BCNVA)、视野和FM-100色觉，并分别在明室环境、暗室环境和暗室伴眩光环境进行对比敏感度检查并记录，分析配戴前后上述视功能参数的变化。

结果：配戴琥珀色滤光镜后UCDVA和BCDVA均优于配戴前(t=-2.32，P<0.001； t=-6.77，P<0.001)，而UCNVA和BCNVA在戴镜前后差异无统计学意义。戴镜后的视野指数(VFI)低于配戴前(t=8.62，P<0.001)、视野平均缺损值(MD)大于配戴前(t=7.73，P<0.001)，FM100色棋检查显示TES和多个分区PES均高于戴镜前(P<0.001)。配戴后明室环境、暗室伴眩光环境下各频段CS值较配戴前提高(P<0.001)，暗室不伴眩光环境下各频段配戴琥珀色滤光镜前后差异无统计学意义。

结论：原发性RP的低视力患者配戴琥珀色滤光镜后UCDVA和BCDVA提高，UCNVA和BCNVA无改变，而视野和辨色能力较戴镜前更差。明室环境及暗室伴眩光环境对比敏感度较戴镜前改善，而暗室不伴眩光环境对比敏感度无明显变化。

METHODS: Self-control before and after study. A total of 30 patients(60 eyes)with low vision who were diagnosed with primary RP in the ophthalmology clinic of Xi'an No.1 Hospital from August 2021 to March 2022 were collected. The uncorrected distance visual acuity(UCDVA), best-corrected distance visual acuity(BCDVA), uncorrected near visual acuity(UCNVA), best-corrected near visual acuity(BCNVA), visual field and Farnsworth-Munsell(FM)-100 color visions were recorded before and after wearing amber filter. The contrast sensitivity(CS)in three visual environments including bright room, darkroom and darkroom with glare was measured and recorded respectively, and the changes of those parameters were analyzed before and after wearing filter.

RESULTS: UCDVA and BCDVA after wearing the filter were better than those before wearing(t=-2.32, P<0.001; t=-6.77, P<0.001), while there was no statistically significant difference in UCNVA and BCNVA before and after wearing filter. The visual field index(VFI)after wearing filter was lower than that before wearing(t=8.62, P<0.001), and the mean defect(MD)of visual field was greater than that before wearing(t=7.73, P<0.001). FM100 color chess test showed that both total error score(TES)and partial error score(PES)in multiple regions were higher than those before wearing filter(P<0.001). After wearing, the CS of each frequency band in the environment of bright room and darkroom with glare was higher than that before wearing(P<0.001), and there was no statistically significant difference in each frequency band before and after wearing amber filter under the environment of darkroom without glare.

CONCLUSION: Patients with low vision of primary RP showed improved UCDVA and BCDVA, but unchanged UCNVA and BCNVA after wearing amber filter, while the visual field and color discrimination were worse than those before wearing filter. The CS of the bright room and darkroom with glare environment was improved than before wearing filter, while there were no significant changes in CS under darkroom without glare.