目的：探究干眼角膜上皮损伤患者的流行病学特征及相关危险因素。方法：回顾2018-07/2019-06期间就诊于北京大学第三医院的干眼角膜上皮损伤患者的门诊病历，对患者性别、年龄、就诊日期、合并症以及同一时期的气象指标进行统计学分析。结果：回顾性分析291名干眼角膜上皮损伤患者，其中有75.3%为女性。21-30岁的青年患者占比最大(26.5%)，青少年(<18岁，5.8%)和老年人(≥61岁，17.2%)较少。然而，中青年患者虽然占比较大，其平均就诊次数较少(5.4±12.4)。春季和冬季是最主要的就诊季节。分析表明，PM10、二氧化硫(SO2)、二氧化氮(NO2)、以及较低的平均相对湿度与干眼角膜上皮损伤显著相关(P<0.05)。结膜炎、白内障、视物模糊以及倒睫是排名前四位的合并症。结论：女性、青年人群干眼角膜上皮损伤问题不容忽视。PM10、SO2、NO2和空气湿度降低与干眼角膜上皮损伤显著相关。对于合并有结膜炎、白内障、视物模糊以及倒睫的干眼患者，更应关注其角膜状况。

AIM: To analyze the characteristics and correlated risk factors of dry eye patients with corneal epithelial defects.METHODS: Outpatient medical records of dry eye patients with corneal epithelial defects at Peking University Third Hospital from July 2018 to June 2019 were retrospectively analyzed. The patients' data including sex, age, visit date, presence of comorbidities, and meteorological indicators at the same period were statistically analyzed.RESULTS: A total of 291 dry eye patients with corneal epithelial defects, of whom 75.3% were female, were retrospectively analyzed. Young patients aged 21-30 made up the most(26.5%), while the proportion of teenagers(<18 years, 5.8%)and the elderly(≥61 years, 17.2%)was low. However, as the largest proportion of this population, young and middle-aged patients tend to experience fewer visits(5.4±12.4). Spring and winter were the main seasons of complaints. The meteorological indicators at the same period including fine-particulate matter with a median aerometric diameter of less than 10μm(PM10), sulfur dioxide(SO2), nitrogen dioxide(NO2), and reduced average relative humidity were found significantly correlated with dry eye corneal epithelial defects(P<0.05). Conjunctivitis, cataracts, blurred vision, and trichiasis ranked the top four comorbidities.CONCLUSION: Dry eye corneal epithelial defects of young and female population cannot be ignored. PM10, SO2, NO2, and reduced humidity are found significantly correlated with dry eye corneal epithelial defects. For dry eye patients with conjunctivitis, cataracts, blurred vision, and trichiasis, more attention should be paid to their corneal conditions.

北京市自然科学基金项目(No.7202229)