目的：探讨优化脉冲光(OPT)治疗蠕形螨睑缘炎的疗效及对眼表功能影响。方法：回顾性研究。选取2018-02/2020-10本院收治的蠕形螨睑缘炎患者127例254眼，根据治疗方式进行分组，对照组63例126眼给予常规热敷、眼部清洁及药物治疗； 观察组64例128眼在对照组基础上给予OPT治疗，均连续治疗6wk。对比两组患者治疗前后蠕形螨计数、Marx线评分、睑脂性状评分、眼表疾病指数(OSDI)评分、非侵入性泪膜破裂时间(NIBUT)、非侵入性泪河高度(NITMH)、泪膜脂质层厚度(LLT)情况，评估安全性。结果：治疗后6wk，两组患者蠕形螨计数、Marx线评分、睑脂性状评分、OSDI评分均较治疗前降低，NIBUT、NITMH及LLT均较治疗前提高，且观察组患者蠕形螨计数、Marx线评分、睑脂性状评分、OSDI评分均显著低于对照组，NIBUT、NITMH及LLT均高于对照组(P<0.001)。两组患者治疗前后眼压未见明显异常，结膜、角膜未见损伤。结论：OPT应用于蠕形螨睑缘炎效果较好，安全性高。

AIM: To investigate the efficacy of optimal pulse technology(OPT)in the treatment of demodex blepharitis and its influence on ocular surface function.METHODS: A retrospective study was conducted from February 2018 to October 2020. A total of 127 patients(254 eyes)with demodex blepharitis were assigned to the observation group and the control group according to the treatment method. The control group(63 patients, 126 eyes)were given conventional hot compress, eye cleansing and drug therapy. On this basis, the observation group(64 patients, 128 eyes)was treated with OPT. Both groups were given 6wk of continuous treatment. Demodex count, Marx's line scores, meibum character scores, ocular surface disease index(OSDI)scores, non-invasive tear break-up time(NIBUT), non-invasive tear meniscus height(NITMH)and lipid layer thickness(LLT)were compared between the two groups, and safety was evaluated.RESULTS: After 6wk of treatment, demodex count, Marx's line scores, meibum character scores and OSDI scores of the two groups decreased. NIBUT, NITMH and LLT increased. Meanwhile, demodex count, Marx's line scores, meibum character scores and OSDI scores of the observation group were significantly lower than those in the control group. NIBUT, NITMH and LLT were longer/larger than those in the control group(P<0.001). No obvious abnormality of intraocular pressure or conjunctival/corneal injury was observed in either group.CONCLUSION:OPT is effective and safe in the treatment of demodex blepharitis.