目的：评价强脉冲光(IPL)联合睑板腺按摩(MGX)治疗睑板腺功能障碍(MGD)相关性干眼(DED)的有效性。

方法：检索中国期刊全文数据库(CNKI)、万方数据库、维普中文期刊数据库(VIP)、中国生物医学文献数据库(CBM)、ClinicalTrials、PubMed、Embase、Web of Science数据库，纳入2017-01/2022-09试验组采用IPL联合MGX，对照组单纯运用MGX治疗MGD相关性干眼的临床随机对照试验研究(RCTs)。采用Review Manager 5.3和Stata 14软件对临床疗效、眼表疾病指数(OSDI)评分、泪膜破裂时间(BUT)、角膜荧光素染色(CFS)评分、泪河高度(TMH)以及睑板腺分泌物性质评分(MGYSS)6个结局指标进行Meta分析。

结果：最终纳入15篇RCTs，MGD相关性干眼患者1 345例。Meta分析结果表明，与对照组相比，试验组治疗MGD相关性干眼可更好的提高临床疗效(OR=4.95， 95%CI：2.76～8.90， Z=5.35， P<0.00001)、BUT(SMD=1.26， 95%CI：0.84～1.69， Z=5.78， P<0.00001)、TMH(SMD=0.37， 95%CI：0.15～0.59， Z=3.33， P=0.0009)，降低OSDI评分(SMD=-0.86， 95%CI：-1.44～-0.27， Z=2.85， P=0.004)以及MGYSS(SMD=-2.43， 95%CI：-4.31～-0.54， Z=2.52， P=0.01)。但在CFS评分差异无统计学意义(SMD=-0.19， 95%CI：-0.46～0.07， Z=1.43， P=0.15)。

结论：IPL联合MGX治疗MGD相关性干眼与单纯运用MGX治疗相比，能提高总体有效率，更好地改善MGD相关性干眼患者的症状和体征。

METHODS: Chinese and English databases such as Chinese national knowledge infrastructure(CNKI), Wanfang, VIP, CBM, ClinicalTrials, PubMed, Embase and Web of Science were searched, and clinical randomized controlled trials(RCTs)using IPL combined with MGX in the experimental group and MGX alone in the control group from January 2017 to September 2022 were included. Six outcome indicators including clinical efficacy, ocular surface disease index(OSDI)score, break-up time(BUT), corneal fluorescein staining(CFS)score, tear meniscus height(TMH)and meibomian gland yielding secretion score(MGYSS)were Meta analyzed by Review Manager 5.3 and Stata 14 software.

RESULTS: A total of 15 RCTs were included, with 1 345 patients with MGD-related dry eye. Meta-analysis results showed that the treatment of MGD-related dry eye in the experimental group improved better clinical efficacy(OR=4.95, 95%CI: 2.76～8.90, Z=5.35, P<0.00001), BUT(SMD=1.26, 95%CI: 0.84～1.69, Z=5.78, P<0.00001), TMH(SMD=0.37, 95%CI: 0.15～0.59, Z=3.33, P=0.0009), and reduced OSDI scores(SMD=-0.86, 95%CI: -1.44～-0.27, Z=2.85, P=0.004)as well as MGYSS(SMD=-2.43, 95%CI: -4.31～-0.54, Z=2.52, P=0.01)than the control group. However, there was no statistically significant difference in CFS scores(SMD=-0.19, 95%CI: -0.46～0.07, Z=1.43, P=0.15).

CONCLUSION: IPL combined with MGX in the treatment of MGD related dry eye can increase the overall effective rate and improve the symptoms and signs of patients with MGD related dry eye better than MGX alone.