目的：探讨配戴Paragon CRT角膜塑形镜后光学治疗区直径的影响因素以及与眼轴增长量的关系。

方法：回顾性临床研究。收集2020-04/2022-09配戴Paragon CRT角膜塑形镜近视患者资料226例226眼。分析戴镜后1mo光学治疗区直径的相关因素以及重叠光学治疗区面积/瞳孔面积比值与戴镜后1a眼轴增长量的关系。

结果：戴镜后1mo，光学治疗区直径与中央角膜厚度呈负相关，与平坦角膜偏心率呈正相关。戴镜后1a，小直径光学区组眼轴增长量(0.25±0.18mm)显著小于大直径光学区组(0.34±0.24mm，P=0.002)，小面积比值组眼轴增长量(0.24±0.19mm)显著小于大面积比值组(0.35±0.23mm，P<0.001)。多因素线性回归分析显示，年龄及重叠光学治疗区面积/瞳孔面积比值两个因素影响眼轴增长(均P<0.05)。

结论：中央角膜越厚、平坦角膜偏心率越小的配戴者光学治疗区直径更小，且光学治疗区直径及重叠光学治疗区面积/瞳孔面积比值均与眼轴增长量相关。

METHODS: Retrospective clinical study. The data of 226 myopic patients(226 eyes)wearing Paragon CRT orthokeratology from April 2020 to September 2022 were collect. The correlated factors of TZD after wearing lens for 1mo, and the relationship between the overlapping treatment zone/ pupil area ratio and the ALG after wearing lens for 1a were analyzed.

RESULTS: After wearing lens for 1mo, the TZD was negatively correlated with central corneal thickness(CCT)and positively correlated with the flat corneal eccentricity. After wearing lens for 1a, the ALG of the small TZD group(0.25±0.18mm)was significantly smaller than that of the large TZD group(0.34±0.24mm, P=0.002), and the ALG of the small area ratio group(0.24±0.19mm)was significantly smaller than that of the large area ratio group(0.35±0.23mm,P<0.001). Age and overlapping treatment zone area/pupil area ratio were significantly associated with the ALG in multivariate linear regression(all P<0.05).

CONCLUSION: The wearers with thicker CCT and smaller flat corneal eccentricity usually had smaller TZD, and both the TZD and the overlapping treatment zone area/pupil area ratio were correlated with the ALG.