目的：探讨4D视觉训练系统联合3D数字化斜弱视视功能矫治系统治疗弱视的效果。方法：前瞻性研究。选取2018-01/2022-01就诊于本院的弱视患儿102例，通过计算机产生的随机数将患儿分成对照组51例采用3D数字化斜弱视视功能矫治系统，观察组51例在对照组基础上联合使用4D视觉训练系统。比较两组患儿治疗总有效率、治疗前后双眼视功能、等效球镜(SE)、眼轴长度(AL)与平均角膜曲率(Km)、最佳矫正视力(BCVA)及视觉诱发电位。结果：观察组治疗总有效率(94.1%)明显高于对照组(74.5%)(P<0.05)； 观察组患儿同时视功能、融合视功能和立体视功能及视功能重建率明显高于对照组(P<0.05)； 两组患儿弱视眼△SE、△AL和△Km比较均无差异(P>0.05)； 两组1°空间与15'空间频率潜伏期均较治疗前明显降低，观察组较对照组下降更为明显(P<0.05)； 两组患儿治疗后BCVA均较治疗前改善，观察组改善更明显(P<0.05)。结论：4D视觉训练系统联合3D数字化斜弱视视功能矫治系统可提高弱视患儿视力，促进双眼同时视、融合视与立体视的重建，不额外增加近视漂移风险，改善视通路功能。

AIM:To investigate the effect of vision therapy system 4D combined with stereoscopic 3D technology training for the treatment of amblyopia.METHODS: Prospective study. A total of 102 children with amblyopia who attended the clinic from January 2018 to January 2022 were selected, and they were randomly assigned into two groups by computer, with 51 cases in each group. Control group received stereoscopic 3D technology training, while observation group participated in vision therapy system 4D on the basis of control group. Then the overall effective rate, binocular visual function, spherical equivalent(SE), axial length(AL), mean corneal curvature(Km), best corrected visual acuity(BCVA)and visual evoked potential were compared between two groups.RESULTS: The overall efficacy rate was 94.1% in observation group, which was obviously higher than control group(74.5%; P<0.05). The improvement in binocular vision parameters simultaneous perception, total fusion, and stereoacuity were all more remarkable in observation group than in control group(P<0.05). The △SE, △AL and △Km yielded no statistical difference between two groups(P>0.05). The latency of two spatial frequencies(1°grid and 15'grid)showed a decline in both groups, and the decline was more notable in observation group than in control group(P<0.05). In both groups, BCVA improved, and the improvement was more significant in observation group compared with control group(P<0.05).CONCLUSION: Application of vision therapy system 4D combined with stereoscopic 3D technology training for amblyopia can effectively ameliorate the visual acuity, promote the reconstruction of simultaneous perception, total fusion, and stereoacuity without additional risk of myopic shift, and improve visual pathway function in children.