目的：利用LipiView眼表面干涉仪和Keratograph 5M眼前节分析仪观察原发性获得性鼻泪管阻塞(PANDO)对泪膜及眼表的影响。方法：自身对照临床试验研究。将2021-09/2022-03我科收治的单侧PANDO且病程在6mo以上的患者40例纳入研究，以健眼作为对照。采用LipiView眼表面干涉仪和Keratograph 5M眼前节分析仪测量并分析双眼泪膜及眼表相关参数的差异。结果：纳入患者患眼非侵入性泪河高度(NITMH)、刺激后NITMH、上睑板腺缺失率、鼻颞侧睫状眼红指数、颞侧结膜眼红指数均高于健眼(P<0.05)，但双眼非侵入性泪膜破裂时间(NIBUT)、下睑板腺缺失率、鼻侧结膜眼红指数、干眼分级、眨眼次数、不完全眨眼率、泪膜脂质层厚度(LLT)均无差异(P>0.05)。结论：PANDO可能导致眼表炎症加重及上睑板腺缺失，损害患者眼表健康，应重视早期PANDO的治疗。

AIM: To investigate the effects of primary acquired nasolacrimal duct obstruction(PANDO)on the tear film and ocular surface using LipiView ocular surface interferometer and Keratograph 5M anterior segment analyzer.METHODS: A self-controlled clinical trials. A total of 40 patients diagnosed with unilateral PANDO for at least 6mo who were admitted to our department from September 2021 to March 2022 were enrolled in the study, and the healthy eyes of the patients were assessed as control group. The LipiView ocular surface interferometer and Keratograph 5M anterior segment analyzer were used to measure the changes in related parameters of the tear film and ocular surface in both eyes.RESULTS: The non-invasive tear meniscus height(NITMH), stimulated NITMH, loss rate of upper meibomian gland, nasal and temporal ciliary redness index, temporal conjunctival redness index of the affected eyes were higher than healthy eyes(P<0.05), but there were no statistical differences in the non-invasive break-up time(NIBUT), loss rate of lower meibomian gland, nasal conjunctival redness index, dry eye grading, blink responses, partial blink rate and lipid layer thickness(LLT)between the both eyes(P>0.05).CONCLUSION: PANDO may lead to the aggravation of ocular surface inflammation and the loss of upper meibomian gland, and damage the ocular surface of patients. Attention should be paid to the early treatment of PANDO.

陕西省重点研发计划项目(No.2023-YBSF-567); 西安市科技计划项目(No.2019115913YX014SF047); 西安市科技计划项目(No.21YXYJ0027)