目的：报告5例药物诱发的双侧急性睫状体脉络膜渗漏(DBACE)和近视漂移，伴或不伴高眼压(OHT)的病例，总结患者的临床特点和DBACE的恢复过程，探讨其可能的病理生理机制。

方法：2017-06/2021-02期间进行的回顾性观察性病例研究。纳入患者接受以下眼部检查：1)最佳矫正视力； 2)眼压(IOP)； 3)裂隙灯显微镜； 4)眼底照相； 5)超声生物显微镜(UBM)； 6)显然验光； 7)眼轴长度和前房深度。所有患者每2d随访一次，直到屈光度完全恢复至病发前状态。

结果：本研究共招募了5名年龄在10-45岁之间的患者，其中包括3名女性和2名男性患者。所有患者均为双侧受累(5/5)，并有近视漂移(5/5)，其中3例患有OHT(3/5)。随着年龄的增长，近视漂移减少，OHT增加。根据OHT，DBACE的动态加重过程分为1期(无OHT的近视漂移)和2期(有OHT的近视漂移)。随着DBACE的恶化，当近视漂移接近或超过最小调节幅度(MAA)时，眼压逐渐升高，DBACE从1期进展到2期。随着停用可疑药物后DBACE的恢复，第2期的DBACE先恢复到1期，然后恢复正常。

结论：DBACE的病理生理机制分为2个阶段，包括1期(无OHT的近视漂移)和2期(有OHT的近视漂移)。这两个阶段之间的转换取决于近视漂移和MAA之间的失衡。

METHODS:A retrospective observational case study conducted from June 2017 to February 2021. The included patients were subjected to a series of ocular examinations listed as follows: 1)best corrected visual acuity; 2)intraocular pressure(IOP); 3)slit-lamp microscopy; 4)fundus photography; 5)ultrasound biomicroscopy(UBM); 6)subjective optometry; 7)axial length and anterior chamber depth. All patients were followed up every 2d until the diopters were completely restored to the state before the disease onset.

RESULTS:In total, 5 patients aged 10-45 years old, including 3 female and 2 male patients, were enrolled in this study. All patients were bilaterally involved(5/5), and had myopic shift(5/5), of whom 3 patients had OHT(3/5). With the increase of age, myopic shift decreased, while OHT increased. Based on OHT, the dynamic aggravation process of DBACE was subdivided into 2 stages, stage 1(myopic shift without OHT)and stage 2(myopic shift with OHT). With the deterioration of DBACE, when myopic shift approached or exceeded the minimum amplitude of accommodation(MAA), IOP gradually rose, and DBACE progressed from stage 1 to stage 2. With the recovery of DBACE after discontinuing the suspicious drugs, DBACE in stage 2 first returned to stage 1, and then returned to normal.

CONCLUSION:Pathophysiological mechanism of DBACE was subdivided into 2 stages, including stage 1(myopic shift without OHT)and stage 2(myopic shift with OHT). The transition between the two stages depends on the imbalance between myopic shift and MAA.