目的：研究单眼屈光参差性弱视患者对一阶光栅锐度和二阶纹理敏感度的感知能力。方法：收集2018-01/2022-12于我院确诊的单眼屈光参差性弱视儿童715例715眼作为弱视组，另选取矫正视力正常儿童745例745眼作为正常对照组。分别检测最佳矫正视力(BCVA)、一阶光栅锐度和(或)二阶纹理敏感度，并分析不同程度弱视患者对一阶光栅锐度和二阶纹理敏感度的感知能力。结果：弱视组与正常对照组一阶光栅锐度(11.58±6.10 vs 20.27±3.47，P<0.001)、二阶纹理敏感度(0.33±0.16 vs 0.12±0.04，P<0.001)均有明显差异，且轻中度弱视患者与重度弱视患者一阶光栅锐度(12.10±6.23 vs 8.13±3.70，P<0.001)和二阶纹理敏感度(0.32±0.16 vs 0.37±0.17，P<0.05)均有明显差异。结论：单眼屈光参差性弱视患者大脑皮层一阶视觉通路和二阶视觉通路均存在不同程度的损伤，重度弱视患者较轻中度弱视患者损伤更为严重。

AIM: To study the perception of first-order grating acuity and second-order spatial contrast sensitivity in patients with monocular anisometropia amblyopia.METHODS:A total of 715 children(715 eyes)diagnosed as monocular anisometropia amblyopia in our hospital from January 2018 to December 2022 were collected as amblyopia group, and 745 children(745 eyes)with normal corrected visual acuity were collected. The best corrected visual acuity(BCVA), first-order grating acuity and/or second-order spatial contrast sensitivity were measured, repectively. The perception ability of amblyopia patients to first-order grating acuity and second-order spatial contrast sensitivity were analyzed.RESULTS:There were significant differences between amblyopia group and normal control group in the perception of first-order grating acuity(11.58±6.10 vs. 20.27±3.47, P<0.001)and second-order spatial contrast sensitivity(0.33±0.16 vs 0.12±0.04, P<0.001). And there were significant differences between mild-to-moderate amblyopia and severe amblyopia patients in first-order grating acuity(12.10±6.23 vs. 8.13±3.70, P<0.001)and second-order spatial contrast sensitivity(0.32±0.16 vs. 0.37±0.17, P<0.05).CONCLUSION: The first-order and second-order visual pathway of the cerebral cortex in children with monocular anisometropia amblyopia have different degrees of damage. The injury of severe amblyopia is more serious than that of mild-to-moderate amblyopia.

2021年度安徽省高校自然科学研究项目(No.KJ2021A0328); 2022年度安徽医科大学第二附属医院转化医学研究科研基金项目(No.2022ZHYJ05)