[关键词]
[摘要]
N6-甲基腺苷(m6A)是真核细胞中最普遍、最丰富和最保守的RNA内部修饰方式。m6A修饰主要通过m6A甲基转移酶、m6A去甲基化酶和m6A甲基化识别蛋白调节RNA的剪接、稳定性、输出、降解和翻译等。近年来的研究发现，m6A甲基化异常可能介导眼部的多种病理过程，参与代谢性、炎症性、退行性眼病和眼部肿瘤的发生发展，如糖尿病视网膜病变、白内障、年龄相关性黄斑变性、葡萄膜黑色素瘤等。本文就m6A甲基化修饰在眼部组织细胞和眼科疾病中的作用进行综述，阐明m6A甲基化在眼病中的潜在分子机制，可能为某些眼科疾病的患者提供新的治疗思路。
[Key word]
[Abstract]
N6-methyladenosine(m6A), the most common, abundant, and conserved RNA modification in eukaryotic cells, regulates RNA splicing, stability, output, degradation and translation through m6A methyltransferase, m6A demethylase, and m6A methylated binding proteins. Recent studies have found that abnormal m6A methylation may mediate a variety of pathological processes in eyes and participate in the occurrence and development of metabolic, inflammatory, degenerative ocular diseases and ocular tumors, such as diabetic retinopathy, cataract, age-related macular degeneration and uveal melanoma. This review aims to summarize the roles of m6A methylation modification in ocular cells and ocular diseases, elucidate the potential molecular mechanisms of m6A methylation in ocular diseases, so as to encourage innovative approaches in the treatment of these ocular diseases.
[中图分类号]
[基金项目]
四川省中医药管理局科学技术研究专项课题(No.2023zd001,2023MS580)
