[关键词]
[摘要]
新生血管性年龄相关性黄斑变性(nARMD)是一种普遍发生的、与年龄相关的严重影响患者视力的视网膜疾病。大量研究显示，脂质代谢紊乱在nARMD的进展中发挥着促进作用，而这种关系涉及到多个因素，包括脂肪酸、胆固醇、脂质代谢基因变异等。脂质代谢紊乱通过刺激氧化应激、抑制自噬，以及二者间的相互作用，引起了视网膜血管的异常和炎症反应，从而加速新生血管的形成，导致黄斑区细胞和组织的损伤。在动物实验中，开发针对脂质代谢紊乱的药物证实了通过调节脂质代谢是治疗nARMD的一种潜在有效策略。基于这一发现，文章对脂质代谢在nARMD进展及治疗中的作用进行综述，旨在为下一步的临床研究提供参考和依据，为nARMD的临床治疗开辟新的思路。
[Key word]
[Abstract]
Neovascular age-related macular degeneration(nARMD)is a prevalent age-related retinal disease that significantly impairs vision. Numerous studies have shown that lipid metabolism disorders contribute to the progression of nARMD. The relationship is complex and involved factors such as fatty acids, cholesterol, variations in lipid metabolism genes, and other influencing factors. Lipid metabolism disorders lead to retinal vascular abnormalities and inflammatory responses by triggering oxidative stress and inhibiting autophagy. This, in turn, accelerates the formation of new blood vessels and causes damage to macular cells and tissues. In animal experiments, drugs designed for lipid metabolism disorders have shown that regulating lipid metabolism could be a potentially effective strategy for treating nARMD. This article reviews the role of lipid metabolism in the progression and treatment of neovascular age-related macular degeneration, aiming to offer new insights for nARMD treatment.
[中图分类号]
[基金项目]
山东省自然科学基金面上项目(No.ZR2023MH069); 潍坊市卫生健康委科研项目(No.WFWSJK-2023-163); 潍坊市青年医学人才托举工程资助
