目的：评价脱细胞猪角膜基质深板层移植治疗感染性角膜炎的有效性、安全性。

方法：前瞻性研究。收集2017-02/ 2020-10在我院经药物保守治疗无效的感染性角膜炎患者17例17眼，应用脱细胞猪角膜基质进行深板层角膜移植手术。术后随访6 mo，观察BCVA、角膜上皮愈合情况、角膜透明情况，并记录有无感染复发以及植片排斥。

结果：所有患者中均顺利完成深板层角膜移植手术，均未发生术中并发症，无失访病例，术后角膜感染均得到有效控制。术后BCVA均较术前改善(P <0.05)。17眼中16眼术后1 mo上皮完全覆盖角膜植片，仅1眼上皮未完全愈合，为病毒性角膜炎的反复发作。术后1.5 mo所有患者上皮均完全愈合。术后1 mo角膜水肿开始改善，其中1眼角膜植片轻度混浊，16眼中重度混浊； 术后3-6 mo角膜透明度稳定，至术后6 mo时4眼完全透明，6眼轻度混浊，6眼中度混浊，1眼重度混浊。随访过程中，无感染复发，有1眼发生眼压升高现象，经治疗后眼压恢复正常。

结论：脱细胞猪角膜基质深板层移植治疗感染性角膜炎，不仅能有效控制感染，缓解患者角膜刺激症状，恢复角膜的解剖与功能，而且能维持良好的透明性，提高患者视力，可作为替代同种异体人角膜。

METHODS:Prospective study. A total of 17 patients(17 eyes)with infectious keratitis who failed to receive conservative treatment in our hospital from February 2017 to October 2020 were collected, and porcine corneal acellular stromal deep lamellar keratoplasty was performed using acellular porcine corneal matrix. The postoperative follow-up was 6 mo, and best corrected visual acuity(BCVA), corneal epithelial healing, corneal transparency were observed, and the recurrence of infection and graft rejection were recorded.

RESULTS:All patients successfully underwent deep lamellar keratoplasty without intraoperative complications, and there were no cases of loss to follow-up. Postoperative corneal infections were effectively controlled, and BCVA was improved(P<0.05). The complete epithelial coverage of the graft was achieved in 16 eyes by 1 mo postoperatively. Only 1 eye did not achieve complete epithelialization within this period, accompanied by relapse of viral keratitis. However, by 1.5 mo postoperatively, all patients had fully healed epithelium. Corneal edema began to improve 1 month after surgery, with 1 eye with mild turbidity and 16 eyes with severe turbidity. Corneal transparency was stable 3-6 mo after surgery, and 4 eyes were completely transparent, 6 eyes were mildly turbid, 6 eyes were moderately turbid, and 1 eye was severely turbid at 6 mo. During the follow-up period, there were no recurrences of infection, while 1 eye experienced elevated intraocular pressure, which was successfully managed with treatment.

CONCLUSION: The acellular porcine corneal stroma deep lamellar keratoplasty for the treatment of infectious keratitis not only effectively controls infection and alleviates corneal irritation symptoms, but also restores corneal anatomy and function. Additionally, it maintains good transparency and improves patients' vision, making it a viable alternative to allogeneic human corneas.