[关键词]
[摘要]
衰老是生物体必经的过程，体内抗氧化能力下降，诱发炎症小体的激活，自噬失调，晶状体内蛋白质错误折叠，导致晶状体混浊。随着年龄增长，褪黑素、谷胱甘肽(GSH)的分泌逐渐减少，促氧化/促炎因子增多，这为年龄相关性白内障(ARC)的形成创造了理想条件。氧化应激、炎症、自噬失调等一系列改变伴随着衰老的发生，同样也是各种疾病发生的基础。褪黑素拥有抗氧化、抗炎、调节自噬和昼夜节律的作用，在年龄相关性黄斑变性(ARMD)、糖尿病视网膜病变(DR)、青光眼(glaucoma)中都展现出了益处。尽管超声乳化晶状体植入术已发展成熟，但耗费医疗资源颇大。文章对褪黑素在ARC的研究进行综述，可能起到预防/延缓ARC的形成，从而减轻患者经济负担，减少医疗资源损耗。
[Key word]
[Abstract]
Aging is a necessary process for organisms.The antioxidant capacity in the body decreases, which induces the activation of inflammasomes, autophagy dysregulation, protein misfolding in the lens, resulting in lens opacification. With the increase of age, the secretion of melatonin and glutathione(GSH)gradually decreased, and the pro-oxidant/pro-inflammatory factors increased, which created ideal conditions for the formation of age-related cataract(ARC). A series of changes such as oxidative stress, inflammation and autophagy dysregulation accompany the occurrence of aging, which is also the basis of various diseases. Melatonin has antioxidant, anti-inflammatory, regulation of autophagy and circadian rhythm effects, and has shown benefits in age-related macular degeneration(ARMD), diabetic retinopathy(DR), and glaucoma. Although phacoemulsification and lens implantation have developed maturely, they consume a lot of medical resources. This article reviews the research of melatonin in ARC, which may prevent/delay the formation of ARC, thereby reducing the economic burden of patients and reducing the loss of medical resources.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(No.82000926); 甘肃省自然科学基金资助项目(No.GSWSKY2022-05); 中国人民解放军联勤保障部队第九四○医院基金资助项目(No.2021yxky033,2023YXKY033,2023YXKY011); 联勤保障部队第九四〇医院高层次人才培养工程(G2层次)(No.2024-G2-4)
