[关键词]
[摘要]
Hippo信号通路在细胞生长、增殖、凋亡和干细胞更新方面起重要作用。Hippo信号通路的异常调节已被证明可导致多种疾病，如癌症、心脏病、肺病、肾病、肝病和免疫功能障碍等。此外，Hippo信号通路失调也会导致多种眼部疾病，因此调节Hippo信号通路的平衡，可能会成为眼部疾病的有效治疗方法。文章综述了Hippo信号通路在眼部疾病中的作用机制以及治疗潜力，并讨论了有关Hippo信号通路的潜在治疗靶点，以期能为眼部疾病的治疗在Hippo信号通路中找到新的靶点和提供新的研究思路。
[Key word]
[Abstract]
Hippo signaling pathway plays an important role in cell growth, proliferation, apoptosis, and stem cell regeneration. Dysregulation of this pathway has been linked to various diseases, such as cancer, heart disease, lung disease, kidney disease, liver disease, and immune dysfunction, as well as ocular diseases. Consequently, regulating the balance of Hippo signaling pathway may be an effective treatment for ocular diseases. This article reviews the mechanism of action and therapeutic potential of Hippo signaling pathway in ocular diseases, and discusses the potential therapeutic targets of the Hippo signaling pathway, to identify new targets and provide new research ideas for treating ocular diseases.
[中图分类号]
[基金项目]
湖南省自然科学基金(No.2023JJ70043); 沈阳市中青年科技创新人才支持计划项目(No.RC210392)
