目的：系统评价低浓度阿托品滴眼液控制青少年近视的疗效和安全性。

方法：计算机检索Wanfang Data、CNKI、VIP、PubMed、Cochrane Library及Embase数据库，检索2010-01/2024-03有关低浓度阿托品滴眼液控制青少年近视的临床研究。由2名研究者独立筛选试验，提取资料，行偏倚风险及质量评价，采用Review Manager5.4软件进行Meta分析。

结果：共纳入17篇文献，共计近视青少年3 764例3 952眼。Meta分析结果显示，与对照组相比，低浓度阿托品能有效减缓眼轴增长\〖MD=-0.15，95%CI(-0.20，-0.10)，P<0.00001\〗，显著控制等效球镜度变化\〖MD=0.39，95%CI(0.29，0.48)，P<0.00001\〗，对瞳孔直径\〖MD=0.80，95%CI(0.33，1.28)，P=0.0010\〗和调节幅度\〖MD=-2.54，95%CI(-4.49，-0.60)，P=0.01\〗具有明显影响。

结论：低浓度阿托品对青少年近视眼轴长度、等效球镜度的控制有良好效果，能显著影响瞳孔直径和调节幅度，能有效延缓近视进展。

METHODS:A computer search was conducted on Wanfang Data, CNKI, VIP, PubMed, Cochrane Library, and Embase databases from January 2010 to March 2024 on clinical studies on low-concentration atropine eye drops for controlling adolescent myopia. Two researchers independently screened trials, extracted data, evaluated risk of bias and quality, and used Review Manager5.4 software to perform Meta-analysis.

RESULTS:A total of 17 articles, involving 3 764 cases and 3 952 eyes, were included. The Meta-analysis showed that compared with the control group, low concentrations of atropine could effectively slow down the growth of axial length \〖MD=-0.15, 95% CI(-0.20, -0.10), P<0.00001\〗, significantly controlled the changes in spherical equivalent \〖MD=0.39, 95% CI(0.29, 0.48), P<0.00001\〗, and had a significant effect on pupil diameter \〖MD=0.80, 95% CI(0.33,1.28), P=0.0010\〗 and amplitude of accommodation \〖MD=-2.54, 95%CI(-4.49, -0.60), P=0.01\〗.

CONCLUSION:Low-concentrations atropine are effective in controlling spherical equivalent and axial length of myopia in adolescents, significantly affecting pupil diameter and amplitude of accommodation, and effectively delaying the progression of myopia.