[关键词]
[摘要]
目的：探讨眼轴长度与角膜曲率半径比值对儿童青少年近视的诊断价值。
方法：计算机检索PubMed、Embase、The Cochrane Library、CNKI、CBM、WanFang Data和VIP数据库，收集有关眼轴长度与角膜曲率半径比值诊断儿童青少年近视的临床研究，检索时间为建库至2023-09-30。提取资料并应用QUADAS-2工具进行文献质量评价； 采用随机效应模型合并诊断试验效应量，并进行Meta回归和亚组分析探究异质性来源。
结果：共纳入10篇文献，涉及研究对象19 872人，Meta分析结果显示，眼轴长度与角膜曲率半径比值诊断儿童青少年近视的合并灵敏度为0.91\〖95%CI(0.90-0.91)\〗，合并特异度为0.84\〖95%CI(0.84-0.85)\〗，SROC曲线下面积为0.95\〖95%CI(0.93-0.96)\〗。
结论：眼轴长度与角膜曲率半径比值可较好判断儿童青少年近视。
[Key word]
[Abstract]
AIM: To investigate the diagnostic value of the axial length/corneal radius of curvature(AL/CR)for myopia in children and adolescents.
METHODS: PubMed, Embase, The Cochrane Library, CNKI, CBM, WanFang Data and VIP databases were searched to collect clinical research on the value of AL/CR in diagnosing myopia in children and adolescents, and the retrieval time was from establishment to September 30, 2023. The QUADAS-2 tool was used to evaluate the quality of the extracted literature. A random-effects model was used to pool diagnostic test data, Meta-regression and subgroup analysis were performed to explore sources of heterogeneity.
RESULTS: A total of 10 articles involving 19 872 study participants were included, and Meta-analysis showed that the pooled sensitivity of the AL/CR for the diagnosis of myopia in children and adolescents was 0.91\〖95%CI(0.90-0.91)\〗, the pooled specificity was 0.84 \〖95%CI(0.84-0.85)\〗, and area under the SROC curve of 0.95 \〖95%CI(0.93-0.96)\〗.
CONCLUSION: The AL/CR is a good indicator of myopia in children and adolescents.
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