目的：探究强脉冲光(IPL)联合睑板腺按摩治疗睑板腺功能障碍(MGD)相关干眼的效果。

方法：回顾性研究。选取2021-10/2023-10本院收治的诊断为MGD相关干眼患者300例300眼(均选取右眼)，根据治疗方式不同分为两组：对照组150例150眼睑板腺按摩治疗，观察组150例150眼联合IPL治疗。比较两组患者疗效以及泪膜稳定性指标\〖泪膜破裂时间(BUT)、泪液分泌量(SⅠt)\〗、眼表疾病指数(OSDI)评分、泪膜脂质层厚度(LLT)、平均客观散射指数(OSI)、泪液中炎性因子的水平\〖白细胞介素-10(IL-10)和IL-6\〗的变化情况。

结果：两组患者治疗后疗效比较有差异(88% vs 74%，P=0.002)。与治疗前比较，治疗8 wk后两组患者OSDI评分、OSI、泪液IL-6水平降低，BUT、SⅠt、LLT、泪液IL-10水平升高，且观察组优于对照组(均P<0.05)。

结论：IPL联合睑板腺按摩治疗MGD干眼患者治疗效果显著，可以改善角膜稳定性和LLT，降低OSI和泪液炎性因子的水平。

METHODS: Retrospectively selected 300 cases(300 right eyes)that diagnosed as MGD-related dry eye and treated in our hospital from October 2021 to October 2023, and they were divided into two groups according to the treatment modalities: 150 cases(150 eyes)in the control group were treated with meibomian gland massage, and 150 cases(150 eyes)in the observation group were treated with combined IPL. The efficacy of the two groups was compared, as well as the changes in tear film stability indexes \〖tear film break-up time(BUT), Schirmer I test(SIT)\〗, ocular surface disease index(OSDI)scores, tear film lipid layer thickness(LLT), mean objective scattering index(OSI), and the levels of inflammatory factors in the tear fluid \〖interleukin-10(IL-10)and IL-6\〗.

RESULTS: There was a difference in efficacy between the two groups of patients after treatment(88% vs 74%, P=0.002). At 8 wk after treatment, OSDI score, OSI, and tear IL-6 levels decreased, while BUT, SIt, LLT, and tear IL-10 levels increased in the two groups, and the observation group was better than the control group(all P<0.05).

CONCLUSION: IPL combined with meibomian gland massage for the treatment of dry eye patients with MGD is therapeutically effective, improving corneal stability and LLT, and reducing levels of OSI and inflammatory factors.