[关键词]
[摘要]
一氧化氮(NO)是在一氧化氮合酶(NOS)催化下，由内皮细胞产生并存在于人体多器官组织中的内皮源性舒张因子，同时也是介导生物体内多种生理病理过程的关键气体信号分子。NO与NOS具有调节人体血管张力，舒张平滑肌，参与炎症反应，传递神经递质等多方面作用，已在一定范围内用于疾病的治疗。近年来眼科疾病发生多呈上升态势，不同程度降低患者生活质量，但大多数疾病治疗方式有限。研究发现，在眼球多部位组织中均可检测到NO与NOS的存在，两者参与眼表及眼底多种疾病的发生及转归过程。文章将NO、NOS与眼部疾病的相关性进行综述，分析其在疾病发生发展中的机制作用，为眼科疾病的临床治疗提供新思路。
[Key word]
[Abstract]
Nitric oxide(NO)is an endothelial-derived relaxing factor produced by endothelial cells and catalyzed by nitric oxide synthase(NOS), which is present in many organs and tissues of the human body. NO is a key gaseous signaling molecule that mediates a variety of physiopathological processes in organisms. NO and NOS have many functions including the regulation of vascular tone, the relaxation of smooth muscle, activation of immune responses and modulation of neuro-transmission. They have been used in the treatment of diseases in a certain field. In recent years, the incidence of ophthalmic diseases has been on the rise, and the quality of life of patients has been reduced. However, treatment for most diseases is limited. It is find that NO and NOS can be detected in various tissue of ocular parts, and they are involved in the occurrence and transformation of many ocular surface and fundus diseases. This article reviews the correlation between them and ocular diseases, analyzes the mechanism and principle of the occurrence and development of diseases, and provides new ideas for the clinical treatment of ophthalmic diseases in the future.
[中图分类号]
[基金项目]
国家自然科学基金项目(No.82305322); 山东省中医药科技发展项目(No.M-2022162); 山东省自然科学基金项目(No.ZR2020QH314)
