目的：观察圆锥角膜患者行角膜交联术后角膜光密度的变化规律。

方法：采用回顾性研究。选取2020-04/2022-04在宁夏眼科医院确诊为进展期圆锥角膜并行角膜交联术的患者32例43眼。Pentacam分析系统将角膜分为前层(前120 μm)、中层及后层(后60 μm)，并依据直径划分为直径0-2、2-6、6-10、10-12 mm及全直径范围五个区域，测量不同范围的角膜光密度。比较术前，术后1、3、6 mo角膜光密度的变化。

结果：纳入患者术前和术后6 mo裸眼视力和最佳矫正视力及眼压比较均有差异(均P<0.05)，角膜内皮细胞比较无差异(P=0.477)。在角膜前层、中层、全层的直径0-2、2-6、6-10 mm及全直径范围内，角膜光密度术后1 mo时到达峰值，术后3 mo与6 mo有所下降，但仍比术前高。角膜光密度在前层及全层范围内与Kmax正相关(r=0.164，P=0.016； r=0.152，P=0.023)。

结论：角膜光密度在角膜交联术后1 mo时达到峰值，随后开始逐步下降，术后6 mo趋于稳定。

METHODS: Retrospective study. A total of 32 patients(43 eyes)with keratoconus in Ningxia Eye Hospital from April 2020 to April 2022 were selected. Pentacam analysis system divided the cornea into three layers: anterior 120 μm, middle layer and posterior 60 μm, and divides it into five regions with diameters of 0-2, 2-6, 6-10, 10-12 mm and full diameter according to the diameter, and measures the CD in different ranges. The changes of CD were compared before operation and at 1, 3 and 6 mo after operation.

RESULTS: There were differences in uncorrected visual acuity, best corrected visual acuity and intraocular pressure before and 6 mo after operation(all P<0.05), and there was no difference in corneal endothelial cells(P=0.477). CD reached its peak at 1 mo after operation, and decreased at 3 mo and 6 mo after operation, but it was still higher than that before operation. There is a significant positive correlation between CD and Kmax in the anterior layer and the whole layer(r=0.164, P=0.016; r=0.152, P=0.023).

CONCLUSION: The values of CD peaked at 1 mo after CXL, then it gradually decreased, tending to become stable at 6 mo postoperatively.