A new method of duplication of the chronic intraocular hypertension model: underwater electrocoagulation
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A new method of duplication of the chronic intraocular hypertension model: underwater electrocoagulation. Int J Ophthalmol

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    Abstract:

    To study the experimental method of inducing the chronic intraocular hypertension in rat eyes. · METHODS: Twenty Wistar rats were randomly divided into ocular hypertension and sham control groups. Intraocular pressure (IOP) was raised by electrocoagulating at least 3 episcleral and limbal veins on the right eye of each rat in ocular hypertension group and its contralateral eye was used as control. At 1, 2, 3, 4 and 8 week after the electrocoagulation of the veins, IOP were measured. · RESULTS: The treatment of electrocoagulation caused a significant IOP increase of the right eyes over the baseline, over the contralateral eyes, and over the sham control eyes (repeated measures ANOVA, P <0.001). At 1 week, IOP was 30.12±5.18mmHg, and maintained the high IOP up to 8 weeks. · CONCLUSION: The chronic intraocular hypertension model could be successfully created by electrocoagulating three or more episcleral and limbal veins.

    Reference
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Hong-Bin Lü,Yan Li, Yuan-Sheng Yuan,/et al.A new method of duplication of the chronic intraocular hypertension model: underwater electrocoagulation. Int J Ophthalmol, 2008,1(1):45-47

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Publication History
  • Received:November 24,2007
  • Revised:February 10,2008