Study of retinal vessel oxygen saturation in ischemic and non-ischemic branch retinal vein occlusion
Author:
Fund Project:

Supported by the National Science & Technology Pillar Program of the Twelfth Five-year Plan (2012BAI08B04); Open Research Funds of the State Key Laboratory of Ophthalmology.

  • Article
  • | |
  • Metrics
  • |
  • Reference [43]
  • |
  • Related [20]
  • | | |
  • Comments
    Abstract:

    AIM: To explore how oxygen saturation in retinal blood vessels is altered in ischemic and non-ischemic branch retinal vein occlusion (BRVO). METHODS: Fifty BRVO eyes were divided into ischemic (n=26) and non-ischemic (n=24) groups, based on fundus fluorescein angiography. Healthy individuals (n=52 and n=48, respectively) were also recruited as controls for the two groups. The mean oxygen saturations of the occluded vessels and central vessels were measured by oximetry in the BRVO and control groups. RESULTS: In the ischemic BRVO group, the occluded arterioles oxygen saturation (SaO2-A, 106.0%±14.3%), instead of the occluded venule oxygen saturation (SaO2-V, 60.8%±9.4%), showed increases when compared with those in the same quadrant vessels (SaO2-A, 86.1%±16.5%) in the contralateral eyes (P<0.05). The oxygen saturations of the central vessels showed similar trends with those of the occluded vessels. In the non-ischemic BRVO group, the occluded and central SaO2-V and SaO2-A showed no significant changes. In both the ischemic and non-ischemic BRVOs, the central SaO2-A was significantly increased when compared to healthy individuals. CONCLUSION: Obvious changes in the occluded and central SaO2-A were found in the ischemic BRVO group, indicating that disorders of oxygen metabolism in the arterioles may participate in the pathogenesis of ischemic BRVO.

    Reference
    1 Rehak J, Rehak M. Branch retinal vein occlusion: pathogenesis, visual prognosis, and treatment modalities. Curr Eye Res 2008;33:111-131.
    2 Anderson B. Ocular effects of changes in oxygen and carbon dioxide tension. Trans Am Ophthalmol Soc 1968;66:423-474.
    3 Rogers S, McIntosh RL, Cheung N, Lim L, Wang JJ, Mitchell P, Kowalski JW, Nguyen H, Wong TY; International Eye Disease Consortium. The prevalence of retinal vein occlusion: pooled data from population studies from the United States, Europe, Asia, and Australia. Ophthalmology 2010;117(2):313-319.
    4 Laouri M, Chen E, Looman M, Gallagher M. The burden of disease of retinal vein occlusion: review of the literature. Eye (Lond) 2011;25(8):981-988.
    5 Hayreh SS, Rojas P, Podhajsky P, Montague P, Woolson RF. Ocular neovascularization with retinal vascular occlusion-III. Incidence of ocular neovascularization with retinal vein occlusion. Ophthalmology 1983;90(5):488-506.
    6 Parodi MB, Bandello F. Branch retinal vein occlusion: classification and treatment. Ophthalmologica 2009;223(5): 298-305.
    7 Parodi MB, DI Stefano G, Ravalico G. Grid laser treatment for exudative retinal detachment secondary to ischemic branch retinal vein occlusion. Retina 2008;28(1):97-102.
    8 Jefferies P, Clemett R, Day T. An anatomical study of retinal arteriovenous crossings and their role in the pathogenesis of retinal branch vein occlusions. Aust N Z J Ophthalmol 1993;21(4):213-217.
    9 Fraenkl SA, Mozaffarieh M, Flammer J. Retinal vein occlusions: the potential impact of a dysregulation of the retinal veins. EPMA J 2010;1:253-261.
    10 Donati G, Pournaras CJ, Pizzolato GP, Tsacopoulos M. Decreased nitric oxide production accounts for secondary arteriolar constriction after retinal branch vein occlusion. Invest Ophthalmol Vis Sci 1997;38(7):1450-1457.
    11 Anderson BJ, Saltzman HA. Retinal oxygen utilization measured by hyperbaric blackout. Arch Ophthalmol 1964;72:792-795.
    12 Avila CP, Bartsch DU, Bitner DG, Cheng L, Mueller AJ, Karavellas MP, Freeman WR. Retinal blood flow measurements in branch retinal vein occlusion using scanning laser Doppler flowmetry. Am J Ophthalmol 1998;126(5):683-690.
    13 Fujio N, Feke GT, Ogasawara H, Goger DG, Yoshida A, McMeel JW. Quantitative circulatory measurements in branch retinal vessel occlusion. Eye (Lond) 1994;8(Pt 3):324-328.
    14 Horio N, Horiguchi M. Retinal blood flow analysis using intraoperative video fluorescein angiography combined with optical fiber-free intravitreal surgery system. Am J Ophthalmol 2004;138(6):1082-1083.
    15 Linsenmeier RA. Effects of light and darkness on oxygen distribution and consumption in the cat retina. J Gen Physiol 1986;88(4):521-542.
    16 Pournaras CJ, Tsacopoulos M, Strommer K, Gilodi N, Leuenberger PM. Experimental retinal branch vein occlusion in miniature pigs induces local tissue hypoxia and vasoproliferative microangiopathy. Ophthalmology 1990;97(10):1321-1328.
    17 Pournaras CJ, Miller JW, Gragoudas ES, Husain D, Munoz JL, Tolentino MJ, Kuroki M, Adamis AP. Systemic hyperoxia decreases vascular endothelial growth factor gene expression in ischemic primate retina. Arch Ophthalmol 1997;115(12):1553-1558.
    18 Noergaard MH, Bach-Holm D, Scherfig E, Bang K, Jensen PK, Kiilgaard JF, Stefánsson E, la Cour M. Dorzolamide increases retinal oxygen tension after branch retinal vein occlusion. Invest Ophthalmol Vis Sci 2008;49(3):1136-1141.
    19 Funk M, Kriechbaum K, Prager F, Benesch T, Georgopoulos M, Zlabinger GJ, Schmidt-Erfurth U. Intraocular concentrations of growth factors and cytokines in retinal vein occlusion and the effect of therapy with bevacizumab. Invest Ophthalmol Vis Sci 2009;50(3):1025-1032.
    20 Recupero SM, Perdicchi A, Scuderi GL, Amodeo S, Medori EM, Leonardi A. Visual acuity in central and branch vein retinal occlusion in the presence of macular edema: 1 year of follow-up. Ann Ophthalmol (Skokie) 2006;38(2):107-110.
    21 Shilling JS, Kohner EM. New vessel formation in retinal branch vein occlusion. Br J Ophthalmol 1976;60(12):810-815.
    22 Novotny HR, Alvis DL. A method of photographing fluorescence in circulating blood in the human retina. Circulation 1961;24:82-86.
    23 Spaide RF, Klancnik JM, Cooney MJ. Retinal Vascular Layers Imaged by Fluorescein Angiography and Optical Coherence Tomography Angiography. JAMA Ophthalmol 2015;133(1):45-50.
    24 Vandewalle E, Abegão Pinto L, Olafsdottir OB, De Clerck E, Stalmans P, Van Calster J, Zeyen T, Stefánsson E, Stalmans I. Oximetry in glaucoma: correlation of metabolic change with structural and functional damage. Acta Ophthalmol 2014;92(2):105-110.
    25 Jorgensen C, Bek T. Increasing oxygen saturation in larger retinal vessels after photocoagulation for diabetic retinopathy. Invest Ophthalmol Vis Sci 2014;55(8):5365-5369.
    26 Hardarson SH, Elfarsson A, Agnarsson BA, Stefánsson E. Retinal oximetry in central retinal artery occlusion. Acta Ophthalmol 2013;91(2):189-190.
    27 Hardarson SH, Stefánsson E. Oxygen saturation in central retinal vein occlusion. Am J Ophthalmol 2010;150(6):871-875.
    28 Hardarson SH, Stefánsson E. Oxygen saturation in branch retinal vein occlusion. Acta Ophthalmol 2012;90(5):466-470.
    29 Jaulim A, Ahmed B, Khanam T, Chatziralli IP. Branch retinal vein occlusion: epidemiology, pathogenesis, risk factors, clinical features, diagnosis, and complications. An update of the literature. Retina 2013;33(5):901-910.
    30 Schweitzer D, Hammer M, Kraft J, Thamm E, Königsdörffer E, Strobel J. In vivo measurement of the oxygen saturation of retinal vessels in healthy volunteers. IEEE Trans Biomed Eng 1999;46(12):1454-1465.
    31 Shui YB, Holekamp NM, Kramer BC, Crowley JR, Wilkins MA, Chu F, Malone PE, Mangers SJ, Hou JH, Siegfried CJ, Beebe DC. The gel state of the vitreous and ascorbate-dependent oxygen consumption: relationship to the etiology of nuclear cataracts. Arch Ophthalmol 2009;127(4):475-482.
    32 Gurram MM. Effect of posterior sub-tenon triamcinolone in macular edema due to non-ischemic vein occlusions. J Clin Diagn Res 2013;7(12):2821-2824.
    33 Behzadian MA, Wang XL, Al-Shabrawey M, Shabrawey M, Caldwell RB. Effects of hypoxia on glial cell expression of angiogenesis-regulating factors VEGF and TGF-beta. Glia 1998;24(2):216-225.
    34 Muraoka Y, Tsujikawa A, Murakami T, Ogino K, Kumagai K, Miyamoto K, Uji A, Yoshimura N. Morphologic and functional changes in retinal vessels associated with branch retinal vein occlusion. Ophthalmology 2013;120(1):91-99.
    35 Singer M, Tan CS, Bell D, Sadda SR. Area of peripheral retinal nonperfusion and treatment response in branch and central retinal vein occlusion. Retina 2014;34(9):1736-1742.
    36 Mikha?lova MA, Sizova MV, Shelankova AV. Pathogenesis of retinal vein occlusions. Vestn Oftalmol 2014;130(2):88-92.
    37 Blondal R, Sturludottir MK, Hardarson SH, Halldorsson GH, Stefánsson E. Reliability of vessel diameter measurements with a retinal oximeter. Graefes Arch Clin Exp Ophthalmol 2011;249(9):1311-1317.
    38 Zhao J, Sastry SM, Sperduto RD, Chew EY, Remaley NA. Arteriovenous crossing patterns in branch retinal vein occlusion. The Eye Disease Case-Control Study Group. Ophthalmology 1993;100(3):423-428.
    39 Christoffersen N L, Larsen M. Pathophysiology and hemodynamics of branch retinal vein occlusion. Ophthalmology 1999;106(11):2054-2062.
    40 Frangieh GT, Green WR, Barraquer-Somers E, Finkelstein D. Histopathologic study of nine branch retinal vein occlusions. Arch Ophthalmol 1982;100(7):1132-1140.
    41 Genevois O, Paques M, Simonutti M, Sercombe R, Seylaz J, Gaudric A, Brouland JP, Sahel J, Vicaut E. Microvascular remodeling after occlusion-recanalization of a branch retinal vein in rats. Invest Ophthalmol Vis Sci 2004;45(2):594-600.
    42 Muqit MM, Saidkasimova S, Keating D, Murdoch JR. Long-term study of vascular perfusion effects following arteriovenous sheathotomy for branch retinal vein occlusion. Acta Ophthalmol 2010;88(3):e57-e65.
    43 Man RE, Sasongko MB, Kawasaki R, Noonan JE, Lo TC, Luu CD, Lamoureux EL, Wang JJ. Associations of retinal oximetry in healthy young adults. Invest Ophthalmol Vis Sci 2014;55(3):1763-1769.
    Cited by
    Comments
    Comments
    分享到微博
    Submit
Get Citation

Lei-Lei Lin, Yan-Min Dong, Yao Zong,/et al.Study of retinal vessel oxygen saturation in ischemic and non-ischemic branch retinal vein occlusion. Int J Ophthalmol, 2016,9(1):99-107

Copy
Share
Article Metrics
  • Abstract:1710
  • PDF: 705
  • HTML: 0
  • Cited by: 0
Publication History
  • Received:May 18,2015
  • Revised:June 29,2015
  • Online: December 29,2015