Home > Archive>Volume 11, Issue 4, 2018 >668-673. DOI:10.18240/ijo.2018.04.22
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Altered intrinsic functional connectivity of the primary visual cortex in youth patients with comitant exotropia: a resting state fMRI study
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Corresponding Author:

Fu-Qing Zhou. Department of Radiology, the First Affiliated Hospital of Nanchang University, No.17, Yongwaizheng Street, Donghu District, Nanchang 330006, Jiangxi Province, China. fq.chou@yahoo.com; Yi Shao. Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, No.17, Yongwaizheng Street, Donghu District, Nanchang 330006, Jiangxi Province, China. freebee99@163.com

Fund Project:

Supported by the National Natural Science Foundation of China (No.81660158; No.81160118; No.81400372).

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    Abstract:

    AIM: To evaluate the differences in the functional connectivity (FC) of the primary visual cortex (V1) between the youth comitant exotropia (CE) patients and health subjects using resting functional magnetic resonance imaging (fMRI) data. METHODS: Totally, 32 CEs (25 males and 7 females) and 32 healthy control subjects (HCs) (25 males and 7 females) were enrolled in the study and underwent the MRI scanning. Two-sample t-test was used to examine differences in FC maps between the CE patients and HCs. RESULTS: The CE patients showed significantly less FC between the left brodmann area (BA17) and left lingual gyrus/cerebellum posterior lobe, right middle occipital gyrus, left precentral gyrus/postcentral gyrus and right inferior parietal lobule/postcentral gyrus. Meanwhile, CE patients showed significantly less FC between right BA17 and right middle occipital gyrus (BA19, 37). CONCLUSION: Our findings show that CE involves abnormal FC in primary visual cortex in many regions, which may underlie the pathologic mechanism of impaired fusion and stereoscopic vision in CEs.

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Pei-Wen Zhu, Xin Huang, Lei Ye,/et al.Altered intrinsic functional connectivity of the primary visual cortex in youth patients with comitant exotropia: a resting state fMRI study. Int J Ophthalmol, 2018,11(4):668-673

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Publication History
  • Received:September 23,2017
  • Revised:January 15,2018
  • Online: April 10,2018
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