Home > Archive>Volume 11, Issue 11, 2018 >1814-1820. DOI:10.18240/ijo.2018.11.13
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Abnormal resting-state functional network centrality in patients with high myopia: evidence from a voxel-wise degree centrality analysis
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Corresponding Author:

Xiao-Rong Wu. Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China. wxr98021@126.com; Jun Wang. Second Department of Respiratory Disease, Jiangxi Provincial People’s Hospital, Nanchang 330006, Jiangxi Province, China. wangjun5087@163.com

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Supported by National Natural Science Foundation of China (No.81760179; No.81360151); Natural Science Foundation of Jiangxi Province (No.20171BAB205046); Jiangxi Province Education Department Key Foundation (No.GJJ160033); Health Development Planning Commission Science Foundation of Jiangxi Province (No.20185118).

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    Abstract:

    AIM: To investigate the functional networks underlying the brain-activity changes of patients with high myopia using the voxel-wise degree centrality (DC) method. METHODS: In total, 38 patients with high myopia (HM) (17 males and 21 females), whose binocular refractive diopter were -6.00 to -7.00 D, and 38 healthy controls (17 males and 21 females), closely matched in age, sex, and education levels, participated in the study. Spontaneous brain activities were evaluated using the voxel-wise DC method. The receiver operating characteristic curve was measured to distinguish patients with HM from healthy controls. Correlation analysis was used to explore the relationship between the observed mean DC values of the different brain areas and the behavioral performance. RESULTS: Compared with healthy controls, HM patients had significantly decreased DC values in the right inferior frontal gyrus/insula, right middle frontal gyrus, and right supramarginal/inferior parietal lobule (P<0.05). In contrast, HM patients had significantly increased DC values in the right cerebellum posterior lobe, left precentral gyrus/postcentral gyrus, and right middle cingulate gyrus (P<0.05). However, no relationship was found between the observed mean DC values of the different brain areas and the behavioral performance (P>0.05). CONCLUSION: HM is associated with abnormalities in many brain regions, which may indicate the neural mechanisms of HM. The altered DC values may be used as a useful biomarker for the brain activity changes in HM patients.

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Yu-Xiang Hu, Jun-Rong He, Bo Yang,/et al.Abnormal resting-state functional network centrality in patients with high myopia: evidence from a voxel-wise degree centrality analysis. Int J Ophthalmol, 2018,11(11):1814-1820

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Publication History
  • Received:January 15,2018
  • Revised:September 10,2018
  • Online: November 07,2018
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