The role of cell mediated immunopathogenesis in thyroid-associated ophthalmopathy

doi:10.18240/ijo.2019.07.24

Home > Archive>Volume 12, Issue 7, 2019 >1209-1214. DOI:10.18240/ijo.2019.07.24

The role of cell mediated immunopathogenesis in thyroid-associated ophthalmopathy
DOI:
                        10.18240/ijo.2019.07.24
                    
Author:
                        Zhen-Mao WangZhen-Mao Wang
Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou 515000, Guangdong Province, China
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Zheng-Yan WangZheng-Yan Wang
The People’s Hospital of Xintai, Xintai 271200, Shandong Province, China
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Yan LuYan Lu
Department of Ophthalmology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu Province, China
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Corresponding Author:Yan Lu. Department of Ophthalmology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu Province, China. luyan366@126.com
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Fund Project:Supported by National Natural Science Foundation of China (No.81200719); China Postdoctoral Science Foundation (No.2013M543579; No.2014T71013); Key Specialized Projects in Nanjing (No.SZDZK2016008).

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Abstract:

Currently, thyroid-associated ophthalmopathy (TAO) lacks effective treatment due to our lack of clarity in its immunopathogenesis. Orbital fibroblasts play a key role in altering inflammation and immune response in TAO, and are considered as the key target and effector cells in its pathogenesis. The orbit infiltrating CD34+ fibrocytes add on to the process by expressing high levels of autoantigens and inflammatory cytokines, while also differentiating into myofibroblasts or adipocytes. This review focuses on the role of orbital fibroblasts and CD34+ fibrocytes in the pathogenesis of TAO, highlighting the basis of emerging treatments.

Key words:thyroid-associated ophthalmopathy; orbital fibroblast; fibrocytes; immunopathogenesis

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Zhen-Mao Wang, Zheng-Yan Wang, Yan Lu. ,/et al.The role of cell mediated immunopathogenesis in thyroid-associated ophthalmopathy. Int J Ophthalmol, 2019,12(7):1209-1214

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Publication History

Received:January 03,2019
Revised:May 21,2019
Adopted:
Online: June 11,2019
Published:

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