Home > Archive>Volume 13, Issue 2, 2020 >263-270. DOI:10.18240/ijo.2020.02.10
HTML XML Export Cite reminder
Altered spontaneous brain activity pattern in patients with ophthalmectomy: an resting-state fMRI study
Author:
Corresponding Author:

Yi Shao. Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, No.17, Yongwaizheng Street, Donghu District, Nanchang 330006, Jiangxi Province, China. freebee99@163.com

Fund Project:

Supported by National Natural Science Foundation of China (No.81660158; No.81400372; No.81460092)

  • Article
    • | |
  • Metrics
    • |
  • Reference
    • |
  • Related [20]
    • |
  • Cited by
    • | |
  • Comments
    Abstract:

    AIM: To use the voxel-wise degree centrality (DC) method to explore the underlying functional network brain-activity in patients with ophthalmectomy. METHODS: A total of 32 ophthalmic surgery patients (10 women and 22 men), and 32 healthy subjects (10 women and 22 men) highly matched in gender, age, and the same operation method. Everyone experienced a resting-state functional magnetic resonance imaging scan. The spontaneous brain activity could be assessed by DC. Correlation analysis was used to explore the relationships between the average DC signal values and behavior performance in different regions. Receiver operating characteristic (ROC) curve analysis was utilized to differentiate between ophthalmectomy patients and healthy controls (HCs). RESULTS: Compared with HCs, ophthalmectomy patients had greatly reduced DC values in left lingual gyrus, bilateral lingual lobe, left cingulate gyrus, and increased DC values of left cerebellum posterior lobe, left middle frontal gyrus1, right supramarginal gyrus, left middle frontal gyrus2, right middle frontal gyrus. However, we did not find that there was a correlation between the average DC values from various brain regions and clinical manifestations. CONCLUSION: Dysfunction may be caused by ophthalmectomy in lots of cerebral areas, which may show the potential pathological mechanism of ophthalmectomy and it is beneficial to clinical diagnosis.

    Reference
    Cited by
Get Citation

Zhang B, Li B, Liu RQ,/et al.Altered spontaneous brain activity pattern in patients with ophthalmectomy: an resting-state fMRI study. Int J Ophthalmol 2020;13(2):263-270

Copy
Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
Publication History
  • Received:August 07,2018
  • Revised:October 29,2019
  • Online: February 03,2020
You are the  Visitors
Governing Body：Department of Health, Provincial Government of Shaanxi, China
Organizer：Xi'an Medical Association of China
Address：Room 11707-08, Building 2, Unit 1, Wanda Plaza, No.8 Yanta North Road, Xi'an 710054, Shaanxi Province, China
Fax：(8629)82245172 Phone：(+8629)82245172/82210956
Email：ijopress@163.com
International Journal of Ophthalmology ® 2025 All Rights Reserved   The terms of CC BY-NC-ND 4.0 are applicable to all open access content.