Home > Archive>Volume 13, Issue 4, 2020 >643-649. DOI:10.18240/ijo.2020.04.18
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Physical activity and risk of age-related cataract
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Chang-Rui Wu. First Affiliated Hospital, Xi’an Jiaotong University College of Medicine, 277 Yanta West Road, Xi’an 710061, Shaanxi Province, China. gxwcr001@163.com; Le Ma. School of Public Health, Xi’an Jiaotong University Health Science Center, 76 Yanta West Road, Xi’an 710061, Shaanxi Province, China. male@mail.xjtu.edu.cn; Yue Yin. School of Public Health, Xi’an Jiaotong University Health Science Center, 76 Yanta West Road, Xi’an 710061, Shaanxi Province, China. lycwr@hotmail.com

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Supported by the National Natural Science Foundation of China (No.81473059); the Natural Science Foundation of Shaanxi Province of China (No.2017JM8041); the China Postdoctoral Science Special Foundation (No.2015T81036).

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    Abstract:

    AIM: To summarize quantitatively the prospective association between physical activity and age-related cataract (ARC) risk. METHODS: PubMed, Embase, Web of Science, and Cochrane Library were systematically searched for all relevant follow up studies until July 2019. Multivariable-adjusted relative risks (RRs) and corresponding 95% confidence intervals (CIs) from individual studies were used to calculate the overall summary estimates. The dose-response relationship was assessed using generalized least-squares trend estimation. RESULTS: Six prospective cohort studies, involving 19 173 cases in 6.2-12.1y follow up of 171 620 participants, were included in the analysis. Increased physical activity was significantly associated with reduced risk of ARC by 10% (RR: 0.90; 95%CI: 0.81, 0.99, P=0.04). Stratified analysis by assessment method for physical activity suggest that studies using metabolic equivalent (MET) per day tended to report a slightly stronger association with ARC (RR: 0.85; 95%CI: 0.81, 0.90, P<0.001) than studies which assessed activity by weekly activity (RR: 0.96; 95%CI: 0.89, 1.03, P=0.24). Dose-response analysis indicated that the risk of ARC decreased by 2% (RR: 0.98; 95%CI: 0.98, 0.99, P<0.001) for every 6 METs per day increase in activity. CONCLUSION: The findings from this Meta-analysis provide additional evidence that increased physical activity is inversely associated with ARC risk dose-responsively.

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Hong Jiang, Li-Na Wang, Yan Liu,/et al.Physical activity and risk of age-related cataract. Int J Ophthalmol, 2020,13(4):643-649

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Publication History
  • Received:May 29,2019
  • Revised:July 24,2019
  • Online: March 03,2020
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