Epigenetics effect on pathogenesis of thyroid-associated ophthalmopathy

doi:10.18240/ijo.2021.09.22

Home > Archive>Volume 14, Issue 9, 2021 >1441-1448. DOI:10.18240/ijo.2021.09.22

Epigenetics effect on pathogenesis of thyroid-associated ophthalmopathy
DOI:
                        10.18240/ijo.2021.09.22
                    
Author:
                        Jia-Min CaoJia-Min Cao
Department of Ophthalmology, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China
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Nuo WangNuo Wang
Department of Ophthalmology, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China
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Shi-Ying HouShi-Ying Hou
Department of Ophthalmology, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
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Xin QiXin Qi
Department of Ophthalmology, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
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Wei XiongWei Xiong
Department of Ophthalmology, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China
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Corresponding Author:Wei Xiong. Department of Ophthalmology, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China. weixiong420@csu.edu.cn
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Fund Project:Supported by the National Natural Science Foundation of China (No.82071006); Natural Science Foundation of Hunan Province (No.2020JJ4129); Independent Exploration and Innovation Project of Graduate Students in Central South University (No.2021zzts1086).

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Abstract:

Thyroid-associated ophthalmopathy (TAO) is an autoimmune disease. Recent studies have found the aberrant epigenetics in TAO, including DNA methylation, non-coding RNAs, and histone modification. Many genes have an aberrant level of methylation in TAO. For example, higher levels are found in CD14, MBP, ANGLE1, LYAR and lower levels in DRD4 and BOLL. Non-coding RNAs are involved in the immune response (miR-146a, miR-155, miR-96, miR-183), fibrosis regulation (miR-146a, miR-21, miR-29), adipogenesis (miR-27) and are thought to play roles in TAO. MicroRNA is also related to the clinical activity score (miR-Let7d-5p) and may be a predictor of glucocorticoid therapy (miR-224-5p). The quantities of H4 in TAO are increased compared with euthyroid control subjects, and the role of histone modifications in Graves’ disease may lead to better understanding of its role in TAO. More studies are needed to explain the role of epigenetics in TAO and provide potential therapeutic strategies.

Key words:thyroid-associated ophthalmopathy; epigenetics; DNA methylation; non-coding RNA; histone modification

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Jia-Min Cao, Nuo Wang, Shi-Ying Hou,/et al.Epigenetics effect on pathogenesis of thyroid-associated ophthalmopathy. Int J Ophthalmol, 2021,14(9):1441-1448

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Publication History

Received:November 01,2020
Revised:January 05,2021
Adopted:
Online: August 23,2021
Published:

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