Ling Ling
Affiliated Eye Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China; Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang 330006, Jiangxi Province, ChinaWen-Feng Liu
Department of Hepatic Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaYu Guo
Department of Radiology, the First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, ChinaRong-Bin Liang
Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang 330006, Jiangxi Province, ChinaHui-Ye Shu
Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang 330006, Jiangxi Province, ChinaLi-Juan Zhang
Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang 330006, Jiangxi Province, ChinaQiu-Yu Li
Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang 330006, Jiangxi Province, ChinaQian-Min Ge
Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang 330006, Jiangxi Province, ChinaYi-Cong Pan
Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang 330006, Jiangxi Province, ChinaYi Shao
Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang 330006, Jiangxi Province, ChinaYi Shao. Department of Ophthalmology, the First Affiliated Hospital of Nanchang University, No.17, Yong Wai Zheng Street, Dong Hu District, Nanchang 330006, Jiangxi Province, China. freebee99@163.com
Supported by the National Natural Science Foundation (No.82160195); Central Government Guides Local Science and Technology Development Foundation (No.20211ZDG02003); Key Research Foundation of Jiangxi Province (No.20181BBG70004; No.20203BBG73059); Excellent Talents Development Project of Jiangxi Province (No.20192BCBL23020).
AIM: To assess changed spontaneous brain activity in hyperthyroid exophthalmos (HE) patients by the amplitude of the low-frequency fluctuation (ALFF) method, and to analyze the correlation between brain activity and ALFF values in these patients. METHODS: Totally 18 HE and 18 hyperthyroid non-exophthalmos (HNE) patients were enrolled. The participants were tested by resting-state functional magnetic resonance imaging, and receiver operating characteristic (ROC) curves were generated to classify the ALFF values of the study population. Pearson’s correlation analysis was utilized to evaluate the relationship between the ALFF values obtained from different brain areas and clinical manifestations. RESULTS: Contrary to HNE patients, we observed lower ALFF values in the left calcarine fissure and surrounding cortex (LCFSC) in HE patients. In the ROC curve analysis of the LCFSC, the area under the curve reflected a high degree of accuracy. In addition, there was positive correlation between mean ALFF values of the LCFSC and the best-corrected visual acuity of the affected eyes. CONCLUSION: The study displays abnormal brain activity in LCFSC in patients with HE, which might suggest pathological mechanism of visual impairment of HE patients.
Ling Ling, Wen-Feng Liu, Yu Guo,/et al.Altered spontaneous brain activity patterns in patients with hyperthyroidism exophthalmos using amplitude of low-frequency fluctuation: a resting-state fMRI study. Int J Ophthalmol, 2021,14(12):1957-1962
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