Home > Archive>Volume 15, Issue 1, 2022 >98-105. DOI:10.18240/ijo.2022.01.15
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Characteristics of macular microvasculature before and after idiopathic macular hole surgery
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Corresponding Author:

Li-Jun Shen. The Affiliated Eye Hospital of Wenzhou Medical University, 618 Fengqi East Road, Hangzhou 310000, Zhejiang Province, China. ljshenysg@163.com

Fund Project:

Supported by the National Natural Science Foundation of China (No.81900910; No.81700884); Natural Science Foundation of Zhejiang Province (No.LQ19H120003; No.LGF21H120005); Key Project Jointly Constructed by Zhejiang Pronvince and Ministry (No.WKJ-ZJ-2037); Basic Scientific Research Project of Wenzhou (No.Y20210194).

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    Abstract:

    AIM: To evaluate the macular microvasculature before and after surgery for idiopathic macular hole (MH) and the association of preoperative vascular parameters with postoperative recovery of visual acuity and configuration. METHODS: Twenty eyes from 20 patients with idiopathic MH were enrolled. Optical coherence tomography angiography (OCTA) images were obtained before, 2wk, 1, and 3mo after vitrectomy with internal limiting membrane peeling. Preoperative foveal avascular zone (FAZ) area and perimeter and regional vessel density (VD) in both layers were compared according to the 3-month best-corrected visual acuity (BCVA). RESULTS: The BCVA improved from 0.98±0.59 (logMAR, Snellen 20/200) preoperatively to 0.30±0.25 (Snellen 20/40) at 3mo postoperatively. The preoperative deep VD was smaller and the FAZ perimeter was larger in the 3-month BCVA<20/32 group (all P<0.05). A significant reduction was observed in FAZ parameters and all VDs 2wk postoperatively. Except for deep perifoveal VD, all VDs recovered only to their preoperative values. The postoperative FAZ parameters were lower during follow-up. Decreases in preoperative deep VDs were correlated with worse postoperative BCVA (Pearson’s r=-0.667 and -0.619, respectively). A larger FAZ perimeter (Spearman’s r=-0.524) and a lower deep perifoveal VD preoperatively (Pearson’s r=0.486) were associated with lower healing stage. CONCLUSION: The status of the deep vasculature may be an indicator of visual acuity in patients with a closed MH. Except for the deep perifoveal region, VD recovers only to preoperative levels.

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Dan Cheng, Ji-Wei Tao, Xue-Ting Yu,/et al.Characteristics of macular microvasculature before and after idiopathic macular hole surgery. Int J Ophthalmol, 2022,15(1):98-105

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Publication History
  • Received:February 07,2021
  • Revised:April 22,2021
  • Online: December 24,2021
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