AIM: To determine the relationship among the macular pigment optical density (MPOD), central macular thickness (CMT) and body mass index (BMI). METHODS: This is a comparative cross-sectional study performed in a single institution. Totally 210 volunteers who met the inclusion criteria were included in this study. The subject’s MPOD was measured using Macula Pigment Screener II (MPS II, by Electron Technology). CMT was measured with Spectral Domain Cirrus Optical Coherence Tomography (OCT), Cirrus (Model 4000, Carl Zeiss Meditec). The information of both MPOD and OCT from both eyes were recorded. The data was analysed using Microsoft? Excel, SPSS, and R (version 3.2.1; R Core Team 2015). RESULTS: There was significant positive correlation between MPOD and CMT (r=0.42, P<0.01) and a significant negative correlation between MPOD and BMI (r=-0.23, P<0.01). CONCLUSION: Our study showed a significant positive correlation between MPOD and CMT. Further study is needed to look at the detailed structure of the fovea and its relationship with MPOD. Our study also found a significant negative correlation between MPOD and BMI, suggesting that a reduction in BMI may increase the density of macula pigment, which can be helpful in preventing age-retinal pigment epitheliitis (ARMD).